研究证实锌缺乏与自闭症早期发展存在联系-华东公共卫生
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研究证实锌缺乏与自闭症早期发展存在联系

[日期:2018-11-09] 来源:合众国际社  作者:华东公共卫生 录入 [字体: ]

为了健康

自闭症与锌

Researchers have confirmed a link between zinc deficiency and the develpment of autism in a study of brain cells' connections from rats' hippocampal neurons. Photo by nickelbabe/pixabay

    1月9日(合众国际社UPI)——在研究大鼠海马神经元与脑细胞的连接时,证实了锌缺乏与自闭症的发展之间存在的联系。
      研究人员说虽然他们的发现这种现象但没有如何预防孤独症,但是这有助于解释发育异常并导致最终的治疗困难。这项发现于星期五发表在《前沿》杂志上。
      孤独症是一种神经发育障碍病症,疾病控制和预防中心在全国11个社区中就发现59名儿童中有1人发病。
      当信号通过连接传递时,进入目标神经元的锌,在那里可以结合两种这样的蛋白质:Shank2和Shank3。反过来,它们会导致组成和功能的变化。
      斯坦福大学的研究者们进行了锌柄介导的AMPAR在突触发育中的成熟机制的实验。
锌与柄蛋白互动作用的阐明。
      对孕妇或婴儿补充锌的自闭症风险没有进行对照研究。

Nov. 9 (UPI) -- A link between zinc deficiency and the development of autism has been confirmed in a study of brain cells' connections from rats' hippocampal neurons.

Although researchers said their findings don't show how to prevent autism, they help explain developmental abnormalities and could lead to eventual treatment. The findings were published Friday in the journal Frontiers.

Autism develops as a neurological and developmental disorder that is prevalent in 1 in 59 children, the Centers for Disease Control and Prevention found in tracking 11 communities across the country.

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The exact cause of autism is not known, but theories include heredity, genetics and medical problems, according to Autism Society. Researchers have been investigating pregnancy or delivery problems, as well as environmental factors that include viral infections, metabolic imbalances and exposure to chemicals.

Zinc deficiency has been studied.

When a signal is transferred via a connection, zinc enters the target neuron where it can bind two such proteins: Shank2 and Shank3. In turn, they cause changes in the composition and function -- or

RELATED Prenatal exposure to antidepressants, antipsychotics not linked to autism risk

Experiments on the mechanism of zinc-Shank-mediated AMPAR maturation in developing synapses were performed by the Stanford scientists.

Understanding the interaction between zinc and Shank proteins

RELATED Genetic technique reverses autism's sensory impairment in mice

No controlled studies of autism risk with zinc supplementation in pregnant women or babies have been studied.

 

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